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Appl Radiat Isot. 2011 Oct;69(10):1390-4. doi: 10.1016/j.apradiso.2011.05.007. Epub 2011 May 18.

Fully automated synthesis of the M₁ receptor agonist [¹¹C]GSK1034702 for clinical use on an Eckert & Ziegler Modular Lab system.

Author information

1
GlaxoSmithKline, Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, London, UK. Mickael.x.huiban@gsk.com

Abstract

A fully automated and GMP compatible synthesis has been developed to reliably label the M₁ receptor agonist GSK1034702 with carbon-11. Stille reaction of the trimethylstannyl precursor with [¹¹C]methyl iodide afforded [¹¹C]GSK1034702 in an estimated 10 ± 3% decay corrected yield. This method utilises the commercially available modular laboratory equipment and provides high purity [¹¹C]GSK1034702 in a formulation suitable for human use.

PMID:
21605979
DOI:
10.1016/j.apradiso.2011.05.007
[Indexed for MEDLINE]

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