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Free Radic Biol Med. 2011 Jul 15;51(2):314-26. doi: 10.1016/j.freeradbiomed.2011.04.031. Epub 2011 Apr 23.

Protein sulfenic acid formation: from cellular damage to redox regulation.

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Department of Molecular and Cellular Interactions, Flanders Institute for Biotechnology, VIB, B-1050 Brussels, Belgium.


Protein sulfenic acid formation has long been regarded as unwanted damage caused by reactive oxygen species (ROS). However, over the past 10 years, accumulating evidence has shown that the reversible oxidation of cysteine thiol groups to sulfenic acid functions as a redox-based signal transduction mechanism. Here, we review the mechanisms of sulfenic acid formation by ROS. We present some of the most important roles played by sulfenic acids in living cells as well as the pathways that regulate sulfenic acid formation. We highlight the experimental tools that have been developed to study the cellular sulfenome and show how computational approaches might help to better understand the mechanisms of sulfenic acid formation.

[Indexed for MEDLINE]

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