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Biochim Biophys Acta. 2011 Aug;1813(8):1495-503. doi: 10.1016/j.bbamcr.2011.05.006. Epub 2011 May 14.

Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?

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1
Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.

Abstract

G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α(2C)-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.

PMID:
21605601
PMCID:
PMC3123388
DOI:
10.1016/j.bbamcr.2011.05.006
[Indexed for MEDLINE]
Free PMC Article
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