Send to

Choose Destination
See comment in PubMed Commons below
Dermatol Surg. 2011 Jun;37(6):744-9. doi: 10.1111/j.1524-4725.2011.01973..x.

The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients.

Author information

Section of Dermatology, Augusta, Georgia Medical College of Georgia, Augusta, Georgia 30904, USA.


Skin cancers are common in organ transplant recipients (OTRs). In this review, we discuss the epidemiology of and risk factors for cutaneous neoplasms, particularly squamous cell carcinoma (SCC) in OTRs. The pathogenesis of SCC is reviewed, as well as the potential mechanisms for tumor progression and metastasis associated with two commonly used immunosuppressive medications: tacrolimus and cyclosporine. Finally, we discuss the mechanism of action and potential preventative use of sirolimus, a member of a newer class of immunosuppressants, the mammalian target of rapamycin inhibitors. The authors have indicated no significant interest with commercial supporters.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wolters Kluwer
    Loading ...
    Support Center