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Acta Paediatr. 2011 Nov;100(11):1448-53. doi: 10.1111/j.1651-2227.2011.02361.x. Epub 2011 Jun 15.

A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax.

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1
Department of Clinical Sciences, Section for Paediatrics, The BUT team, Lund University, Sweden.

Abstract

AIM:

To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective.

METHOD:

Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-α-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery.

RESULTS:

The combined therapy resolved the symptoms in the acute phase, and both patients have since been free of symptoms for >2 years.

CONCLUSION:

The successful addition of a low anticoagulant, low molecular weight heparin (tafoxiparin) to the treatment protocol in two paediatric cases of the GSS may justify the use of this approach in similar cases.

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