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Inflamm Bowel Dis. 2012 Feb;18(2):372-90. doi: 10.1002/ibd.21751. Epub 2011 May 20.

Characterization of the gastrointestinal microbiota in health and inflammatory bowel disease.

Author information

1
St Vincent's Hospital, Melbourne, Australia.

Abstract

The enteric bacterial flora play a key role in maintaining health. Inflammatory bowel disease is associated with quantitative and qualitative alterations in the microbiota. Early characterization of the microbiota involved culture-dependent techniques. The advent of metagenomic techniques, however, allows for structural and functional characterization using culture-independent methods. Changes in diversity, together with quantitative alterations in specific bacterial species, have been identified. The functional significance of these changes, and their pathogenic role, remain to be elucidated.

PMID:
21604329
DOI:
10.1002/ibd.21751
[Indexed for MEDLINE]

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