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World J Clin Oncol. 2011 Feb 10;2(2):115-9. doi: 10.5306/wjco.v2.i2.115.

Glucan-immunostimulant, adjuvant, potential drug.

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Vaclav Vetvicka, Department of Pathology, University of Louisville, Louisville, KY 40202, United States.


β-glucans belong to a group of biologically active natural compounds called biological response modifiers. These substances represent highly conserved structural components of cell walls in fungi, yeast, grain and seaweed. Despite almost 160 years of intensive research, the exact mechanisms of their action remain unsolved. The significant role of glucans in cancer treatment, infection immunity, stress reduction and restoration of damaged bone marrow has already been established. The present review focuses on the various less known but potentially significant roles glucans might play in medicine. In summary, glucan might represent the most important natural immunomodulator.


Biological Response Modifiers; CR3; Cancer; Glucan; Immunity; Immunomodulators; Resveratrol

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