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Trends Genet. 2011 Jul;27(7):267-76. doi: 10.1016/j.tig.2011.04.002. Epub 2011 May 24.

Functional consequences of bidirectional promoters.

Author information

1
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

Abstract

Several studies have shown that promoters of protein-coding genes are origins of pervasive non-coding RNA transcription and can initiate transcription in both directions. However, only recently have researchers begun to elucidate the functional implications of this bidirectionality and non-coding RNA production. Increasing evidence indicates that non-coding transcription at promoters influences the expression of protein-coding genes, revealing a new layer of transcriptional regulation. This regulation acts at multiple levels, from modifying local chromatin to enabling regional signal spreading and more distal regulation. Moreover, the bidirectional activity of a promoter is regulated at multiple points during transcription, giving rise to diverse types of transcripts.

PMID:
21601935
PMCID:
PMC3123404
DOI:
10.1016/j.tig.2011.04.002
[Indexed for MEDLINE]
Free PMC Article

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