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Auris Nasus Larynx. 2012 Feb;39(1):48-52. doi: 10.1016/j.anl.2011.04.002. Epub 2011 May 20.

Effect of prehydration on nasal mucociliary clearance in low relative humidity.

Author information

1
Saga Nutraceuticals Research Institute1, Otsuka Pharmaceutical Co., Ltd. 5006-5 Omagari, Yoshinogari, Kanzaki, Saga 842-0195, Japan. h_oozawa@research.otsuka.co.jp

Abstract

OBJECTIVE:

Nasal mucociliary clearance, which plays an important role in defending the respiratory system, tends to decrease under conditions of low relative humidity (RH). The purpose of this randomized cross-over study was to investigate the preventive effect of prehydration on nasal mucociliary clearance under low RH conditions.

METHODS:

Fourteen young healthy subjects were assigned to three interventions: prehydration (6ml/kg body weight) using water (W), prehydration using a carbohydrate-electrolyte beverage (CE), and control conditions (Cont) with no prehydration. For each intervention trial, subjects sat for 4h in an environmental chamber (23°C, 10% RH). Nasal mucociliary clearance was measured by the saccharin transit time (ST). Furthermore, a dry sensation of the mucosa, urine volume, and body weight were measured at the baseline, 2h and 4h after entering the environmental chamber, respectively.

RESULTS:

ST was prolonged under the Cont conditions after entering the environmental chamber. Prehydration with CE led to a significantly lower ST compared to the Cont pretreatment at 2h, whereas the W trial showed no significance difference in comparison to the Cont values.

CONCLUSION:

These results suggest that prehydration with a carbohydrate-electrolyte beverage is therefore beneficial for maintaining better nasal mucociliary clearance at least for 2h under low RH conditions.

PMID:
21601396
DOI:
10.1016/j.anl.2011.04.002
[Indexed for MEDLINE]

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