An immunohistochemical study of sinonasal hemangiopericytoma

Auris Nasus Larynx. 2011 Dec;38(6):743-6. doi: 10.1016/j.anl.2011.04.009. Epub 2011 May 23.

Abstract

We present herein the imaging and pathological features of a 28-year-old male with a sinonasal hemangiopericytoma-like tumor occupying the left nasal meatus. At the initial visit, a nasal polyp was suspected, but, as the patient was bleeding readily, an angiomatoid lesion was also regarded as a possible diagnosis. Based on a thorough histopathological analysis, a sinonasal hemangiopericytoma-like tumor was diagnosed. Hematoxylin and eosin staining also showed a mild degree of nuclear pleomorphism and a slight increase in mitotic activity, and immunohistochemical studies using anti-CD34, MIB-1, and Vimentin antibodies were useful for distinguishing the hemangiopericytoma-like tumor from true hemangiopericytoma and a solitary fibrous tumor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD34 / analysis
  • Hemangiopericytoma / metabolism
  • Hemangiopericytoma / pathology*
  • Hemangiopericytoma / surgery
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen / analysis
  • Male
  • Nose Neoplasms / metabolism
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / surgery
  • Paranasal Sinuses
  • Vimentin / analysis

Substances

  • Antigens, CD34
  • Ki-67 Antigen
  • Vimentin