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Carbohydr Res. 2011 Aug 16;346(11):1342-6. doi: 10.1016/j.carres.2011.04.035. Epub 2011 May 3.

Structure of type 3Gn coaggregation receptor polysaccharide from Streptococcus cristatus LS4.

Author information

1
Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, United States.

Abstract

The presence of a novel coaggregation receptor polysaccharide (RPS) on the dental plaque isolate Streptococcus cristatus LS4 was suggested by this strain's antigenic and coaggregation properties. Examination of RPS isolated from strain LS4 by a combination of 2-dimensional and pseudo 3-dimensional single quantum heteronuclear NMR methods that included detection of (13)C chemical shifts at high resolution revealed the following repeat unit structure: →6)-β-d-Galf-(1→6)-β-d-GalpNAc-(1→3)-α-d-Galp-(1→P→6)-α-d-Galp-(1→3)-β-L-Rhap-(1→4)-β-d-Glcp-(1→. The identification of this polysaccharide as RPS3Gn, a new structural type, was established by the α-d-Galp-containing epitope of RPS serotype 3 and Gn recognition motif (i.e., β-d-GalpNAc (1→3)-α-d-Galp) for coaggregation with other bacteria.

PMID:
21601178
PMCID:
PMC3534726
DOI:
10.1016/j.carres.2011.04.035
[Indexed for MEDLINE]
Free PMC Article

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