α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8. doi: 10.1016/j.bmcl.2011.04.085. Epub 2011 Apr 24.

Abstract

We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies. ATQ3 activity is dependent upon reversible 2e-redox-cycling. ATQ3 may represent a broader class of unappreciated dietary-derived phytomolecular redox motifs that digitally encode biochemical data using redox state as a means to sense and transfer information essential for cellular function.

MeSH terms

  • Aging / drug effects*
  • Aging / physiology
  • Animals
  • Antioxidants / chemistry
  • Antioxidants / metabolism*
  • Antioxidants / pharmacology*
  • Benzoquinones / chemistry*
  • Benzoquinones / pharmacology*
  • Cells, Cultured
  • Dogs
  • Dose-Response Relationship, Drug
  • Humans
  • Mice
  • Molecular Structure
  • Oxidative Stress / drug effects*
  • Rats
  • Tocotrienols
  • Vitamin E / analogs & derivatives
  • Vitamin E / chemistry
  • Vitamin E / pharmacology

Substances

  • Antioxidants
  • Benzoquinones
  • Tocotrienols
  • Vitamin E
  • quinone
  • tocotrienol, alpha