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Comput Med Imaging Graph. 2011 Oct-Dec;35(7-8):603-15. doi: 10.1016/j.compmedimag.2011.02.005. Epub 2011 May 19.

Multi-resolution graph-based analysis of histopathological whole slide images: application to mitotic cell extraction and visualization.

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  • 1Université de Caen Basse-Normandie, Caen, France.


In this paper, we present a graph-based multi-resolution approach for mitosis extraction in breast cancer histological whole slide images. The proposed segmentation uses a multi-resolution approach which reproduces the slide examination done by a pathologist. Each resolution level is analyzed with a focus of attention resulting from a coarser resolution level analysis. At each resolution level, a spatial refinement by label regularization is performed to obtain more accurate segmentation around boundaries. The proposed segmentation is fully unsupervised by using domain specific knowledge.

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