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J Mol Cell Cardiol. 2012 Feb;52(2):351-8. doi: 10.1016/j.yjmcc.2011.05.002. Epub 2011 May 11.

AKAPs: the architectural underpinnings of local cAMP signaling.

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1
Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33101, USA.

Abstract

The cAMP-dependent protein kinase A (PKA) is targeted to specific compartments in the cardiac myocyte by A-kinase anchoring proteins (AKAPs), a diverse set of scaffold proteins that have been implicated in the regulation of excitation-contraction coupling and cardiac remodeling. AKAPs bind not only PKA, but also a large variety of structural and signaling molecules. In this review, we discuss the basic concepts underlying compartmentation of cAMP and PKA signaling, as well as a few of the individual AKAPs that have been shown to be functionally relevant in the heart. This article is part of a Special Issue entitled "Local Signaling in Myocytes".

PMID:
21600214
PMCID:
PMC3168680
DOI:
10.1016/j.yjmcc.2011.05.002
[Indexed for MEDLINE]
Free PMC Article
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