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Cancer Invest. 2011 Jun;29(5):360-4. doi: 10.3109/07357907.2011.584587.

Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia.

Author information

1
University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, Hematology/Oncology Unit, First Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Athens, Greece. mbraouda@yahoo.co.uk

Abstract

The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases.

PMID:
21599512
DOI:
10.3109/07357907.2011.584587
[Indexed for MEDLINE]

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