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Nat Rev Immunol. 2011 Jun;11(6):416-26. doi: 10.1038/nri2986. Epub 2011 May 20.

The insider's guide to leukocyte integrin signalling and function.

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Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, UK.


The activation of leukocyte integrins through diverse receptors results in transformation of the integrin from a bent, resting form to an extended conformation, which has at least two states of ligand-binding activity. This highly regulated activation process is essential for T cell migration and the formation of an immunological synapse. The signalling events that drive integrin activation are complex. Some key players have been well-characterized, but other aspects of the signalling mechanisms involved are still unclear. This Review focuses on the integrin lymphocyte function-associated antigen 1 (LFA1; also known as αLβ2 integrin), which is expressed by T cells, and explores how disparate signalling pathways synergize to regulate LFA1 activity.

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