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Diabetes Res Clin Pract. 2011 Jul;93(1):10-6. doi: 10.1016/j.diabres.2011.02.034. Epub 2011 May 18.

Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently.

Author information

1
Department of Endocrinology and Metabolism, Shanghai Minhang District Central Hospital, Shanghai 201100, China.

Abstract

OBJECTIVE:

Fibroblast growth factor (FGF21) has beneficial effects on lipolysis. Highly sensitive C-reactive protein (hs-CRP) is a predictor of type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). This study aimed to determine the levels of serum FGF21 and hs-CRP in newly diagnosed type 2 diabetes patients with and without NAFLD, and further explored the correlation between FGF21 with hs-CRP in newly diagnosed type 2 DM.

RESEARCH DESIGN AND METHODS:

69 patients with newly diagnosed type 2 DM and 30 normal subjects were included in the study. FGF21 and hs-CRP were measured by ELISA kits. The severity of NAFLD was measured by ultrasound.

RESULTS:

Serum FGF21 in newly diagnosed type 2 DM with NAFLD group were significantly increased (p<0.01). There was no difference for the FGF21 level in normal control group and newly diagnosed type 2 DM without NFALD group. In type 2 DM group, the FGF21 level was positively correlated with hsCRP (r=0.417, p<0.001). In multiple stepwise regression models, only hsCRP was a significantly independent determinant for serum FGF21.

CONCLUSIONS:

Serum levels of FGF21 are closely related to liver steatosis in newly diagnosed type 2 DM patients.

PMID:
21596453
DOI:
10.1016/j.diabres.2011.02.034
[Indexed for MEDLINE]

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