Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome

A Ramsingh; A Hixson; B Duceman; J Slack

doi:10.1128/JVI.64.6.3078-3081.1990

Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome

J Virol. 1990 Jun;64(6):3078-81. doi: 10.1128/JVI.64.6.3078-3081.1990.

Authors

A Ramsingh¹, A Hixson, B Duceman, J Slack

Affiliation

¹ Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201-0509.

Abstract

A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Glucose / metabolism
Chimera
Cloning, Molecular
Coxsackievirus Infections / blood
Coxsackievirus Infections / pathology*
DNA, Viral / genetics
Enterovirus B, Human / genetics
Enterovirus B, Human / pathogenicity*
Genes, Viral*
Mice
Mice, Inbred Strains
RNA, Viral / genetics
Spleen / pathology*
Virulence / genetics

Substances

Blood Glucose
DNA, Viral
RNA, Viral