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Ocul Immunol Inflamm. 2011 Jun;19(3):216-8. doi: 10.3109/09273948.2011.562341.

Successful treatment of chronic pseudophakic macular edema (Irvine-Gass syndrome) with interferon alpha: a report of three cases.

Author information

1
Centre for Ophthalmology, University of Tübingen, Tübingen, Germany. christoph.deuter@med.uni-tuebingen.de

Abstract

PURPOSE:

To describe treatment of chronic Irvine-Gass syndrome (CME) with interferon (IFN) alpha.

METHODS:

Interventional retrospective case series. IFN alpha-2a was administered at a dose of 3 million IU/day subcutaneously for 4 weeks, and was tapered thereafter. Treatment efficacy was assessed by best-corrected visual acuity (BCVA) and by optical coherence tomography (OCT).

RESULTS:

Three patients (4 eyes) with chronic Irvine-Gass syndrome were treated. Ineffective pretreatment included local and systemic corticosteroids. Within 4 weeks, IFN alpha led to resolution of CME in all eyes. BCVA improved in 3 eyes and remained unchanged in 1 eye. During follow-up of 3-11 months no relapse of CME occurred. No systemic or local side effects were noted.

CONCLUSIONS:

IFN alpha has been demonstrated to be a successful and well-tolerated treatment option for resistant chronic pseudophakic CME. Further studies are necessary to evaluate the role of IFN alpha in Irvine-Gass syndrome.

PMID:
21595541
DOI:
10.3109/09273948.2011.562341
[Indexed for MEDLINE]

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