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Nature. 2011 May 19;473(7347):326-35. doi: 10.1038/nature10147.

Heart regeneration.

Author information

  • 1Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA.

Abstract

Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00474461 NCT00587990 NCT00893360.

PMID:
21593865
PMCID:
PMC4091722
DOI:
10.1038/nature10147
[PubMed - indexed for MEDLINE]
Free PMC Article
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