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Nat Rev Cancer. 2011 Jun;11(6):450-7. doi: 10.1038/nrc3063. Epub 2011 May 19.

Human cancers express mutator phenotypes: origin, consequences and targeting.

Author information

1
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA. laloeb@u.washington.edu

Abstract

Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.

PMID:
21593786
PMCID:
PMC4007007
DOI:
10.1038/nrc3063
[Indexed for MEDLINE]
Free PMC Article

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