Format

Send to

Choose Destination
Mol Biol Evol. 2011 Nov;28(11):2973-81. doi: 10.1093/molbev/msr134. Epub 2011 May 18.

A cell-molecular approach predicts vertebrate evolution.

Author information

1
Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. jtorday@labiomed.org

Abstract

In contrast to the conventional use of genes to determine the evolution of phenotypes, we have functionally integrated epithelial-mesenchymal interactions that have facilitated lung phylogeny and ontogeny in response to major geologic epochs. As such, this model reveals the underlying principles of lung physiology based on the evolutionary interactions between internal and external selection pressures, providing a novel understanding of lung biology. As a result, it predicts how cell-molecular changes in this process can cause disease and offers counterintuitive insights to diagnosis and treatment based on evolutionary principles.

PMID:
21593047
PMCID:
PMC3199438
DOI:
10.1093/molbev/msr134
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center