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Clin Neurophysiol. 2011 Nov;122(11):2227-35. doi: 10.1016/j.clinph.2011.04.011. Epub 2011 May 17.

Lempel-Ziv complexity in schizophrenia: a MEG study.

Author information

1
Department of Psychiatry and Psychological Medicine, Complutense University, Madrid, Spain. aferlucas@med.ucm.es

Abstract

OBJECTIVE:

The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it.

METHODS:

Fifteen patients (age range 23-42 years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42 years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated.

RESULTS:

Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity.

CONCLUSIONS:

Results demonstrated that SCH patients failed to follow the "normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases.

SIGNIFICANCE:

Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.

PMID:
21592856
DOI:
10.1016/j.clinph.2011.04.011
[Indexed for MEDLINE]

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