Format

Send to

Choose Destination
Trends Endocrinol Metab. 2011 Aug;22(8):318-24. doi: 10.1016/j.tem.2011.04.001. Epub 2011 May 17.

Fat caves: caveolae, lipid trafficking and lipid metabolism in adipocytes.

Author information

1
Department of Biochemistry Boston University School of Medicine, 72 East Concord St., Boston, MA 02118, USA. ppilch@bu.edu

Abstract

Caveolae are subdomains of the eukaryotic cell surface, so named because they resemble little caves, being small omega-shaped invaginations of the plasma membrane into the cytosol. They are present in many cell types, and are especially abundant in adipocytes, in which they have been implicated as playing a role in lipid metabolism. Thus, mice and humans lacking caveolae have small adipocytes and exhibit lipodystrophies along with other physiological abnormalities. In this review, we examine the evidence supporting the role of caveolae in adipocyte lipid metabolism in the context of the protein and lipid composition of these structures.

PMID:
21592817
PMCID:
PMC3149783
DOI:
10.1016/j.tem.2011.04.001
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center