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Curr Opin Biotechnol. 2011 Dec;22(6):800-8. doi: 10.1016/j.copbio.2011.04.013. Epub 2011 May 16.

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation.

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1
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

Glycosyltransferases (GTs) are ubiquitous in nature and are required for the transfer of sugars to a variety of important biomolecules. This essential enzyme family has been a focus of attention from both the perspective of a potential drug target and a catalyst for the development of vaccines, biopharmaceuticals and small molecule therapeutics. This review attempts to consolidate the emerging lessons from Leloir (nucleotide-dependent) GT structural biology studies and recent applications of these fundamentals toward rational engineering of glycosylation catalysts.

PMID:
21592771
PMCID:
PMC3163058
DOI:
10.1016/j.copbio.2011.04.013
[Indexed for MEDLINE]
Free PMC Article
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