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J Pediatr. 2011 Jul;159(1):152-154.e3. doi: 10.1016/j.jpeds.2011.03.057. Epub 2011 May 18.

Pharmacokinetics of levetiracetam in neonates with seizures.

Author information

1
Perinatal Institute, Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. stephanie.merhar@cchmc.org

Abstract

The pharmacokinetics of levetiracetam were determined prospectively in 18 neonates with seizures. Neonates were found to have lower clearance, higher volume of distribution, and a longer half-life as compared with older children and adults. Mild somnolence was the only adverse effect.

PMID:
21592494
PMCID:
PMC3789844
DOI:
10.1016/j.jpeds.2011.03.057
[Indexed for MEDLINE]
Free PMC Article
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