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Brain Res. 1990 Mar 12;511(1):163-4.

A subset of local interneurons generate slow inhibitory postsynaptic potentials in hippocampal neurons.

Author information

1
Center for Neuroscience, Weizmann Institute of Science, Rehovot, Israel.

Abstract

Topical application of 4-aminopyridine (4-AP) onto hippocampal slices produced spontaneous repetitive large hyperpolarizing potentials in CA1 neurons. This effect of 4-AP was blocked by a new GABAB receptor antagonist, 2-hydroxy-saclofen. 2-Hydroxy-saclofen also blocked slow IPSPs evoked by stimulation of stratum radiatum. It is suggested that 4-AP-evoked slow hyperpolarizing potentials are in fact slow IPSPs evoked by activation of a selective subset of interneurons which do not produce fast IPSPs.

PMID:
2158854
DOI:
10.1016/0006-8993(90)90236-5
[Indexed for MEDLINE]

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