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J Comput Assist Tomogr. 2011 May-Jun;35(3):332-6. doi: 10.1097/RCT.0b013e318219fe76.

Role of diffusion-weighted magnetic resonance imaging in characterization of renal tumors.

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1
Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University Hospital, Mansoura, Egypt. arazek@mans.edu.eg

Abstract

OBJECTIVE:

To evaluate the role of diffusion-weighted magnetic resonance (MR) imaging in the characterization of renal tumors.

MATERIALS AND METHODS:

Prospective study was conducted on 52 consecutive patients (24 males and 28 females) with renal tumor. They underwent diffusion-weighted echo planar MR imaging of the abdomen with b-factor of 0 and 800 seconds/mm². The apparent diffusion coefficient (ADC) value of the renal tumor was calculated and correlated with histopathological results.

RESULTS:

The mean ADC value of malignant renal tumors (1.56 ± 0.26 × 10⁻³ mm²/s) was significantly different (P = 0.001) from that of benign tumors (1.87 ± 0.50 × 10⁻³ mm²/s). Selection of 1.84 × 10⁻³ mm²/s as a cutoff point of ADC value to predict renal malignancy revealed accuracy of 89%, sensitivity of 89%, and specificity of 89%. The cutoff point of ADC value to differentiate renal cell carcinoma (RCC) from other malignancy (1.15 × 10⁻³ mm²/s) revealed 72% accuracy, 95% sensitivity, 50% specificity. The cutoff point of ADC value used to differentiate clear and papillary RCC from other subtypes of RCC was 1.84 × 10⁻³ mm²/s with an accuracy of 89%, sensitivity of 89%, and specificity of 89%.

CONCLUSION:

Apparent diffusion coefficient value can differentiate benign from malignant renal tumors and may be helpful for the differentiation of the histologic subtypes of RCC.

PMID:
21586925
DOI:
10.1097/RCT.0b013e318219fe76
[Indexed for MEDLINE]
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