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Plant Signal Behav. 2011 Jun;6(6):905-10. Epub 2011 Jun 1.

Diverging functions among calreticulin isoforms in higher plants.

Author information

1
Center for Molecular Protein Science, Biochemistry and Biophysical Chemistry, Lund University, Lund, Sweden.

Abstract

The ER chaperone calreticulin plays vital roles in numerous cellular processes, including Ca2+-homeostasis, apoptosis, and cell adhesion, in animal cells. Although calreticulin has been systematically characterized in animal cells, the focus has been on one of the isoforms. However, recent advances in the plant calreticulin field have revealed functional divergence of calreticulin isoforms. While two of the plant isoforms appear to work within a general ER chaperone framework, the third isoform is associated with folding of receptors for brassinosteroids and bacterial peptides. Hence, the discovery of functional specialization of plant calreticulins opens up new vistas for calreticulins also in the animal field.

PMID:
21586899
PMCID:
PMC3218502
[Indexed for MEDLINE]
Free PMC Article

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