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Indian J Ophthalmol. 2011 May-Jun;59(3):191-6. doi: 10.4103/0301-4738.81023.

Comparative role of intravitreal ranibizumab versus bevacizumab in choroidal neovascular membrane in age-related macular degeneration.

Author information

1
B. B. Eye Foundation, 2/5, Sarat Bose Road, Kolkata - 700 020, India. drpartha_biswas07@yahoo.co.in

Abstract

CONTEXT:

Ranibizumab and bevacizumab are used widely for treating patients with choroidal neovascular membrane (CNVM) secondary to age-related macular degeneration (AMD).

AIMS:

To determine and compare the efficacy and safety of intravitreal ranibizumab and bevacizumab in treatment of CNVM due to AMD.

SETTINGS AND DESIGN:

Prospective comparative case series carried out in an eye institute and eye department of a hospital in Kolkata, India.

MATERIALS AND METHODS:

One hundred and four eyes with CNVM due to AMD were randomized into two groups. Group A (n=54; 24 occult) received monthly intravitreal ranibizumab injections (0.5 mg in 0.05 ml) and Group B (n=50; 22 occult) received monthly bevacizumab injections (1.25 mg in 0.05 ml) for 3 consecutive months and then as per study criteria. Data analysis done using SPSS software. P-value of <0.05 was considered statistically significant.

RESULTS:

The mean best corrected visual acuity (BCVA) in the ranibizumab group increased from 58.19 Early Treatment Diabetic Retinopathy Study (ETDRS) letters at baseline to 64 ETDRS letters at month 3 (P<0.001). In bevacizumab group mean BCVA increased from 56.80 to 61.72 ETDRS letters at month 3 (P<0.001). At the end of 18 months, there was no statistically significant difference between groups A and B with respect to change in BCVA (P=0.563) or central macular thickness (CMT; P=0.281), as measured by optical coherence tomography (Stratus OCT 3000). No significant sight-threatening complications developed.

CONCLUSIONS:

Ranibizumab and bevacizumab are equally safe and efficacious in treating CNVM due to AMD.

PMID:
21586838
PMCID:
PMC3120237
DOI:
10.4103/0301-4738.81023
[Indexed for MEDLINE]
Free PMC Article

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