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Ann Rheum Dis. 2011 Aug;70(8):1468-70. doi: 10.1136/ard.2010.148619. Epub 2011 May 17.

Validation of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: slight improvement over the 1987 ACR criteria.

Author information

  • 1Department of Rheumatology, Jan van Breemen Research Institute I Reade, Amsterdam, The Netherlands. k.britsemmer@reade.nl

Erratum in

  • Ann Rheum Dis. 2011 Nov;70(11):2060. van Tuyl, Lilian [corrected to van Tuyl, L H].

Abstract

BACKGROUND:

Recently, an American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) collaboration developed new classification criteria for rheumatoid arthritis (RA).

OBJECTIVE:

To evaluate the diagnostic and discriminative ability of these new criteria compared with the 1987 ACR criteria and the Visser decision rule.

METHODS:

455 patients with early arthritis were studied. The diagnostic performance of the criteria was evaluated using methotrexate treatment within 1 year, expert opinion RA and erosive disease as 'gold standards'. Erosive disease was defined as a 0-3 year change in radiographic score of ≥5.

RESULTS:

The discriminative ability of the three criteria sets (2010 ACR/EULAR, 1987 ACR criteria and Visser algorithm) was similar with areas under the curve of 0.71-0.78 ('gold standard' methotrexate), 0.74-0.80 (gold standard expert opinion RA) and 0.63-0.67 (gold standard erosive disease after 3 years). The sensitivity of the 2010 ACR/EULAR criteria was highest with 0.85 (gold standard methotrexate). 86% of patients with RA and 51% of 'non-RA' patients according to the new criteria used methotrexate.

CONCLUSION:

The 2010 ACR/EULAR criteria were slightly more sensitive, but otherwise performed similarly to the older criteria. A high percentage of 'non-RA' patients used methotrexate, the gold standard for RA. The ability of the new criteria to identify patients with erosive disease was low, possibly owing to the effect of intensive treatment.

[PubMed - indexed for MEDLINE]
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