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Nature. 1990 Apr 26;344(6269):836-41.

G0 is a major growth cone protein subject to regulation by GAP-43.

Author information

1
Developmental Biology Laboratory, Massachusetts General Hospital, Boston.

Abstract

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-gamma-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0 in the growth cone may be regulated by intracellular as well as extracellular signals.

PMID:
2158629
DOI:
10.1038/344836a0
[Indexed for MEDLINE]

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