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Trends Biochem Sci. 1990 Mar;15(3):108-12.

Mechanism and evolution of the uncoupling protein of brown adipose tissue.

Author information

1
Institut für Physikalische Biochemie, Universität München, FRG.

Abstract

The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH(-)-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.

PMID:
2158156
DOI:
10.1016/0968-0004(90)90194-g
[Indexed for MEDLINE]

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