Format

Send to

Choose Destination
Am J Obstet Gynecol. 2011 Aug;205(2):132.e1-12. doi: 10.1016/j.ajog.2011.03.049. Epub 2011 Apr 8.

C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study.

Author information

1
Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications.

STUDY DESIGN:

CRP levels were measured in early pregnancy in 6016 women. Main outcome measures were fetal growth in each trimester and neonatal complications.

RESULTS:

As compared to the reference group (CRP levels<5 mg/L), elevated maternal CRP levels (≥25 mg/L) were associated with lower estimated fetal weight in third trimester and lower weight at birth (differences: -29 g, 95% confidence interval [CI], -58 to 0 and -128 g, 95% CI, -195 to -60, respectively). Elevated maternal CRP levels were also associated with an increased risk of a small size for gestational age in the offspring (adjusted odds ratio, 2.94; 95% CI, 1.61-5.36).

CONCLUSION:

Maternal CRP levels in early pregnancy are associated with fetal growth restriction and increased risks of neonatal complications.

PMID:
21575931
DOI:
10.1016/j.ajog.2011.03.049
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center