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Breast Cancer Res. 2011 Apr 21;13(2):208. doi: 10.1186/bcr2836.

Stress and breast cancer: from epidemiology to molecular biology.

Author information

1
Center for Cancer Therapeutics, Ottawa Hospital Research Institute, 501 Smyth Rd, TOHCC 3rd floor, Ottawa, ON, K1H 8L6, Canada. lantonova@ohri.ca

Abstract

Stress exposure has been proposed to contribute to the etiology of breast cancer. However, the validity of this assertion and the possible mechanisms involved are not well established. Epidemiologic studies differ in their assessment of the relative contribution of stress to breast cancer risk, while physiological studies propose a clear connection but lack the knowledge of intracellular pathways involved. The present review aims to consolidate the findings from different fields of research (including epidemiology, physiology, and molecular biology) in order to present a comprehensive picture of what we know to date about the role of stress in breast cancer development.

PMID:
21575279
PMCID:
PMC3219182
DOI:
10.1186/bcr2836
[Indexed for MEDLINE]
Free PMC Article

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