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Brain Res. 1990 Feb 26;510(1):158-60.

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.

Author information

1
CNS Diseases Research, G.D. Searle & Company St. Louis, MO 63198.

Abstract

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.

PMID:
2157524
[Indexed for MEDLINE]

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