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Indian J Pharmacol. 2011 Apr;43(2):176-9. doi: 10.4103/0253-7613.77357.

Evaluation of efficacy of duloxetine in stress urinary incontinence in women.

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1
Department of Pharmacology, Hassan Institute of Medical Sciences, Hassan, India.

Abstract

OBJECTIVE:

The purpose of this study has been to assess the efficacy of duloxetine, a selective inhibitor of serotonin and norepinephrine reuptake, in the treatment of stress urinary incontinence (SUI) in women.

MATERIALS AND METHODS:

The study included 50 women aged above 18 years with a predominant symptom of stress urinary incontinence (SUI). The case definition included a predominant symptom of SUI with a weekly incontinence episode frequency (IEF) of seven or greater and a positive cough stress test. All the patients received duloxetine 20 mg twice daily for 12 weeks. The primary outcome variables included the IEF and improvement in quality of life. Paired Student's 't' test was used to analyze changes in IEF.

RESULTS:

The improvement with duloxetine treatment was found in 40 out of 50 patients. Remaining 10 patients did not show any improvement with duloxetine and discontinued the treatment. In 40 patients, the mean baseline IEF was 12.5/week. At the end of three months treatment, IEF was six/week. This shows a statistically significant reduction in the IEF. Also, there was a good improvement in quality of life with 65% of patients in the "very much better" and "much better" categories according to PGI-I scale. In the remaining 10 patients, there was no significant improvement after one month of treatment and patients underwent surgery.

CONCLUSIONS:

The findings support duloxetine as a potential treatment for women with stress urinary incontinence.

KEYWORDS:

Duloxetine hydrochloride; norepinephrine serotonin reuptake inhibitor; quality of life; stress urinary incontinence

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