Format

Send to

Choose Destination
Curr Bladder Dysfunct Rep. 2010 Aug 26;5(4):219-224.

Role of Purinergic Signaling in Voiding Dysfunction.

Author information

1
Division of Urology, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

Purinergic signaling is a term that relates to adenosine triphosphate binding to its receptor (purinergic receptors such as P2X and P2Y subtypes). This pathway has been implicated in bladder functional disorders related to interstitial cystitis/painful bladder syndrome, neurogenic bladder secondary to spinal cord injury, lower urinary tract symptoms, diabetes, and aging. Purinergic signaling occurs at multiple sites, including the central nervous system, peripheral motor and sensory nerves, detrusor smooth muscle, and bladder urothelium. Future pharmacologic agents to treat bladder functional disorders may be able to target purinergic signaling at one or more of these sites.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center