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Nat Neurosci. 2011 Jun;14(6):685-7. doi: 10.1038/nn.2820. Epub 2011 May 15.

Skn-1a (Pou2f3) specifies taste receptor cell lineage.

Author information

1
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. imatsumoto@monell.org

Erratum in

  • Nat Neurosci. 2011 Jun;14(6):following 687.
  • Nat Neurosci. 2011 Sep;14(9):1217.

Abstract

Functional diversification of taste cells is crucial for proper discrimination of taste qualities. We found the homeodomain protein Skn-1a (Pou2f3) to be expressed in sweet, umami and bitter taste cells. Skn-1a-deficient mice lacked electrophysiological and behavioral responses to sweet, umami and bitter tastes, as a result of a complete absence of sweet, umami and bitter cells and the concomitant expansion of sour cells. Skn-1a is critical for generating and balancing the diverse composition of taste cells.

PMID:
21572433
PMCID:
PMC3390744
DOI:
10.1038/nn.2820
[Indexed for MEDLINE]
Free PMC Article

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