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Clin Neurophysiol. 2011 Nov;122(11):2128-38. doi: 10.1016/j.clinph.2011.04.017. Epub 2011 May 14.

Reduced movement-related β desynchronisation in juvenile myoclonic epilepsy: a MEG study of task specific cortical modulation.

Author information

1
The Epilepsy Unit, University Hospital of Wales, Cardiff CF14 4XW, UK. hamandik@cf.ac.uk

Abstract

OBJECTIVE:

We investigated differences in task induced responses in occipital and sensorimotor cortex between patients with juvenile myclonic epilepsy (JME) and healthy controls .

METHODS:

Twelve patients with JME and 12 age-matched non-epilepsy volunteers performed visual and motor tasks during MEG. We used synthetic aperture magnetometry to localise areas of task-related oscillatory modulations, performed time-frequency analyses on the locations of peak task related power changes and compared power and frequency modulation at these locations between patients and controls.

RESULTS:

Patients with JME had significantly reduced pre-movement beta event-related desynchronisation in the motor task compared to controls. No significant differences were seen in other motor-related responses, or visual oscillatory responses.

CONCLUSIONS:

Altered beta event-related desynchronisation may represent network specific dysfunction in JME possibly through GABAergic dysfunction.

SIGNIFICANCE:

Characterising task specific cortical responses in epilepsy offers the potential to understand the patho-physiological basis of seizures and provide a window on disease and treatment effects.

PMID:
21571587
DOI:
10.1016/j.clinph.2011.04.017
[Indexed for MEDLINE]

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