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J Control Release. 2011 Oct 30;155(2):200-10. doi: 10.1016/j.jconrel.2011.04.027. Epub 2011 May 5.

New pharmaceutical applications for macromolecular binders.

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Faculty of Pharmacy, Université de Montréal, PO Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada.


Macromolecular binders consist of polymers, dendrimers, and oligomers with binding properties for endogenous or exogenous substrates. This field, at the frontier of host/guest chemistry and pharmacology, has met a renewed interest in the past decade due to the clinical success of several sequestrants, like sevelamer hydrochloride (Renagel®) or sugammadex (Bridion®). In many instances, multivalent binding by the macromolecular drugs can modify the properties of the substrate, and may prevent it from reaching its site of action and/or trigger a biological response. From small (e.g., ions) to larger substrates (e.g., bacteria and cells), this review presents the state-of-the-art of macromolecular binders and provides detailed illustrative examples of recent developments bearing much promise for future pharmaceutical applications.

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