Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Pharmacol. 2011 Oct;11(5):501-7. doi: 10.1016/j.coph.2011.04.009. Epub 2011 May 12.

Non-invasive imaging in experimental medicine for drug development.

Author information

1
GSK Clinical Imaging Centre, Hammersmith Hospital, GlaxoSmithKline Medicines Discovery and Development, UK. paul.m.matthews@gsk.com

Abstract

Clinical imaging offers a range of methods for the support of drug development that are able to address major questions related to target validation and molecule biodistribution, target interactions and pharmacodynamics. Here we review recent innovative applications of positron emission tomography (PET) and magnetic resonance imaging (MRI). New approaches to human target validation exploring MRI or PET biomarker changes related to allelic variation at candidate target loci can contribute to human target validation. PET molecular imaging can define molecule biodistribution directly and, if an appropriate, target-specific radioligand is available, be employed in small experimental medicine studies to provide plasma pharmacokinetic-target occupancy data to guide dose selection. An enlarging range of imaging biomarkers for pharmacodynamic studies is enabling imaging experimental medicine studies to assess the potential efficacy of new therapeutic molecules. Integration of these approaches promises improvements in therapeutic molecule differentiation and may contribute in ways that would improve the value proposition for use of a new drug through patient stratification.

PMID:
21570913
DOI:
10.1016/j.coph.2011.04.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center