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Infect Genet Evol. 2011 Aug;11(6):1208-17. doi: 10.1016/j.meegid.2011.04.031. Epub 2011 May 5.

Molecular evolution of human species D adenoviruses.

Author information

1
Howe Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA. USA.

Abstract

Adenoviruses are medium-sized double stranded DNA viruses that infect vertebrates. Human adenoviruses cause an array of diseases. Currently there are 56 human adenovirus types recognized and characterized within seven species (A-G). Of those types, a majority belongs to species D. In this review, the genomic conservation and diversity are examined among human adenoviruses within species D, particularly in contrast to other human adenovirus species. Specifically, homologous recombination is presented as a driving force for the molecular evolution of human adenoviruses and the emergence of new adenovirus pathogens.

PMID:
21570490
PMCID:
PMC3139803
DOI:
10.1016/j.meegid.2011.04.031
[Indexed for MEDLINE]
Free PMC Article

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