Format

Send to

Choose Destination
Clin Neurophysiol. 2011 Nov;122(11):2121-7. doi: 10.1016/j.clinph.2011.04.013. Epub 2011 May 12.

Lateralization of interictal spikes after corpus callosotomy.

Author information

1
Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Miyagi, Japan. epinetmi@gmail.com

Abstract

OBJECTIVE:

Corpus callosotomy may limit secondary bilateral synchrony into the primary epileptogenic hemisphere. This study investigated whether pre-operative EEG can predict post-operative spike lateralization.

METHODS:

The subjects included 14 patients with medically intractable drop attacks who underwent total corpus callosotomy. Pre-operative patterns of inter-hemispheric propagation were quantified by peak-latency analysis with the template-based spike averaging technique.

RESULTS:

Postoperative lateralization of interictal spikes was observed in 5 of the 14 patients. Inter-hemispheric latency was significantly longer in these 5 patients (mean 14.0 ms, range from 0 to 78 ms, versus mean 5.2 ms, range from 0 to 29 ms, p<0.01). The lateralization occurred in association with the presence of structural lesions (p<0.05). The post-operative spikes were lateralized to the lesion side in 3 of 4 patients with unilateral epileptogenic lesion. Three patients presented one-way inter-hemispheric propagation pattern pre-operatively. The post-operative spikes were lateralized to the hemisphere of the leading spikes in two.

CONCLUSIONS:

Interictal spikes are lateralized to the epileptogenic hemisphere in some patients after callosotomy. Lateralization can be expected in the presence of structural lesions and/or longer inter-hemispheric latency.

SIGNIFICANCE:

Analysis of pre-operative EEG spikes may predict the primary epileptogenic hemisphere before corpus callosotomy.

PMID:
21570340
DOI:
10.1016/j.clinph.2011.04.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center