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Bioorg Med Chem Lett. 2011 Jun 15;21(12):3682-5. doi: 10.1016/j.bmcl.2011.04.084. Epub 2011 Apr 24.

Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines.

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1
NovaBay Pharmaceuticals Inc., Emeryville, CA 94608, United States.

Abstract

Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.

PMID:
21570284
DOI:
10.1016/j.bmcl.2011.04.084
[Indexed for MEDLINE]
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