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Adv Drug Deliv Rev. 2012 Jan;64(1):29-39. doi: 10.1016/j.addr.2011.04.006. Epub 2011 May 3.

Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor.

Author information

1
Division of Pharmaceutics, College of Pharmacy, the Ohio State University, Columbus, OH 43210, USA.

Abstract

Advances in molecular medicines have led to identification of promising targets on cellular and molecular levels. These targets are located in extracellular and intracellular compartments. The latter include cytosol, nucleus, mitochondrion, Golgi apparatus and endoplasmic reticulum. This report gives an overview on the barriers to delivering nanomedicines to various target sites within a solid tumor, the experimental approaches to overcome such barriers, and the potential utility of nanotechnology.

PMID:
21569804
PMCID:
PMC3378679
DOI:
10.1016/j.addr.2011.04.006
[Indexed for MEDLINE]
Free PMC Article

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