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J Am Chem Soc. 2011 Jun 8;133(22):8528-30. doi: 10.1021/ja2028712. Epub 2011 May 17.

Primer preactivation of peptidoglycan polymerases.

Author information

1
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Peptidoglycan glycosyltransferases are highly conserved bacterial enzymes that catalyze glycan strand polymerization to build the cell wall. Because the cell wall is essential for bacterial cell survival, these glycosyltransferases are potential antibiotic targets, but a detailed understanding of their mechanisms is lacking. Here we show that a synthetic peptidoglycan fragment that mimics the elongating polymer chain activates peptidoglycan glycosyltransferases by bypassing the rate-limiting initiation step.

PMID:
21568328
PMCID:
PMC3119865
DOI:
10.1021/ja2028712
[Indexed for MEDLINE]
Free PMC Article

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