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Int J Oncol. 2011 Aug;39(2):301-9. doi: 10.3892/ijo.2011.1035. Epub 2011 May 10.

Molecular targets of selenium in prostate cancer prevention (Review).

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Division of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung Sumedang Km.21, Jatinangor 45363, Indonesia.


Prostate cancer is one of the leading causes of cancer-related deaths among males. Although use of the micro-nutrient selenium in prostate cancer clinical trials is limited, the outcomes indicate that selenium is a promising treatment. Furthermore, selenium inhibits prostate cancer through multiple mechanisms, and it is beneficial in controlling the development of this disease. This review highlights the latest epidemiological and biomolecular research on selenium in prostate cancer, as well as its prospects for future clinical use.

[Indexed for MEDLINE]

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