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J Biol Chem. 2011 Jul 8;286(27):23645-51. doi: 10.1074/jbc.R110.174052. Epub 2011 May 12.

Building protein-protein interaction networks with proteomics and informatics tools.

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1
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.

Abstract

The systematic characterization of the whole interactomes of different model organisms has revealed that the eukaryotic proteome is highly interconnected. Therefore, biological research is progressively shifting away from classical approaches that focus only on a few proteins toward whole protein interaction networks to describe the relationship of proteins in biological processes. In this minireview, we survey the most common methods for the systematic identification of protein interactions and exemplify different strategies for the generation of protein interaction networks. In particular, we will focus on the recent development of protein interaction networks derived from quantitative proteomics data sets.

PMID:
21566121
PMCID:
PMC3129144
DOI:
10.1074/jbc.R110.174052
[Indexed for MEDLINE]
Free PMC Article
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