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Trends Biochem Sci. 2011 Aug;36(8):433-43. doi: 10.1016/j.tibs.2011.04.002. Epub 2011 May 11.

Secretins: dynamic channels for protein transport across membranes.

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1
Department of Biochemistry, University of Washington, Seattle, WA, USA.

Abstract

Secretins form megadalton bacterial-membrane channels in at least four sophisticated multiprotein systems that are crucial for translocation of proteins and assembled fibers across the outer membrane of many species of bacteria. Secretin subunits contain multiple domains, which interact with numerous other proteins, including pilotins, secretion-system partner proteins, and exoproteins. Our understanding of the structure of secretins is rapidly progressing, and it is now recognized that features common to all secretins include a cylindrical arrangement of 12-15 subunits, a large periplasmic vestibule with a wide opening at one end and a periplasmic gate at the other. Secretins might also play a key role in the biogenesis of their cognate secretion systems.

PMID:
21565514
PMCID:
PMC3155655
DOI:
10.1016/j.tibs.2011.04.002
[Indexed for MEDLINE]
Free PMC Article
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